Hi

I think you can search for signed interactions using WGCNA R package. I believe Genemania gives you a coexpression network.

https://horvath.genetics.ucla.edu/html/CoexpressionNetwork/Rpackages/WGCNA/

Read this before

https://peterlangfelder.com/2018/11/25/signed-or-unsigned-which-network-type-is-preferable/

Thank you for the answer. yes, Genemania does provide coexpression network but it also provided genetic interaction network on which I am currently working. correlation sign between a pair of genes can indeed give some idea about their activatory or inhibitory role in the relationship but is there some other database that lists down the activatory/inhibitory relationship between pair of genes?

There are scattered databases based on specific diseases as you cannot have same gene expression throughout. But you could try

http://www.coexpedia.org/search.php

http://seek.princeton.edu/

Hi

The relationship (activation or inhibition) between two genes can be judged by co-expression, positive correlation means that the two genes may be activation relationship, and negative correlations are opposite.

As for judging the direction of interaction, I understand that you want to know which gene is upstream and which one is downstream. I have a few ideas to give you a reference.

With regards

That does give me some great direction. I will try and check these out. Thank you so much.