I have been trying to load hydrophobic drug into the chitosan NPs. But here I am facing quite difficulty in loading into it. Please suggest me any hydrophobic moieties or any techniques for higher encapsulation
There are so many literature available regarding to encapsulation preparation using chitosan as a coating material.
First u have to prepared micro-nano emulsion of the targeted drug. You can added Chitosan during the emulsion praparation as a thicker or after the process.
After emulsion formation u should added aqueous solution of cross linking agent (STP). You have to optimize the chitosan Nd STP concentration.