Your animals could be insulin resistant, have you done an insulin tolerance test?
Insulin resistant, maybe, but then you would see the inverse, no? High insulin with normal to high glucose. Sounds rather like a defect in insulin production or secretion. Or there is some problem with insulinotropic hormone production in the intestine. Interesting phenotype...
Sence leptin decrease insulin secretion, it is not suprising that with greatly increase of a leptin level, beta cells do not secrete enough insulin to compesate for high glucose. The development of a significant degree of hyperglycemia could be the combination of insulin resistance and, or liver hyperproduction of glucose. However, disorder could be associated with fatty liver, or steatohepatitis. Focus on this, IR-test, liver bioopsies could be done. Obesity and Insulin resistance are closely related to hepatic steatosis and higer leptin concentration.
although the facts r answered by this statement that the mice r opbese but u r contradicting urself by saying they have high glucose ,leptin and insulin levels and r obese although ur main question is why insulin levels r not increasing despite raised glucose and leptin levels
- Badges
- Science topic