Now there are amino acid powders. I want to dissolve it into a high-concentration mother liquor for cell culture. What kind of dissolution is more appropriate (I tried to dissolve it with water before, but the solubility is relatively low, and some amino acids are insoluble). If you want to use it for small In vivo experiment in mice——what kind of solvent is better for injection (DMSO?), Please experienced bosses for advice or two, thank you very much
Dear Zhang Xinyu
Please refer to the link below. You may get some useful information.
https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1177&context=oa_diss
Hope this is helpful.
Best.
Dear Zhang Xinyu many thanks for sharing this very interesting technical question with the RG community. For a really useful overview on the properties and solubility of amino acids please have a look at the following instructive review article:
Amino acids in the cultivation of mammalian cells
Article Amino acids in the cultivation of mammalian cells
Fortunately this review is freely available as public full text on RG, so that you can download it as pdf file. Also please see this relevant literature reference:
Solubilities Studies of Basic Amino Acids
Article Solubilities Studies of Basic Amino Acids
(see attached pdf file)
I hope this helps. Good luck with your research and best wishes!
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