How to dissolve 15mg/kg CBD in DMSO for i.p injection to rat?

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Jasmine Pahle

Did you consider administering the drug via the drinking water?

Shian-Ren Lin

Hi Samiee,

I refer to the product information of cannabidiol from Cayman Chemical.

https://www.caymanchem.com/product/90080/cannabidiol

Solubility of cannabidiol in DMSO is 50 mg/mL which is much sufficient for diluting to DMSO:saline. You could try dissolving cannabidol with DMSO in 30 mg/mL or higher, and then serial dilute to 3 mg/mL (15 mg/kg for 20 g mice and 100 uL injection volume) with saline. Another choice is corn oil which could use for replacing saline as corn oil.