Currently I am working on a microfluidic chip. An integral part of it should be a semi-permeable membrane which allows the flow of H2O and smaller ions (nothing bigger than a dinucleotide) but effectively blocks all DNA bigger than 12 nt.
For in situ polymerisation I use PEGDA (~MW = 700, others are in the shelf), a photostarter (Darocur 1153) and some water. Polymerisation starts with UV exposure and so far everything goes fine, the structure is where I need it to be and the mechanical stability also according to the requirement.
Is there a way to calculate the pore size upfront or a table where I can look up which composition leads to which result?
You can read the following links:
1. https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-9-24
2. https://pubmed.ncbi.nlm.nih.gov/21210509/
3. Article Evaluation of methods for pore generation and their influenc...
You might find some answer about mesh size of PEGDA hydrogel (but with longer chains) in the following article:
Article Characterization of permeability and network structure of in...
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