Now lets assume I have a certain enzyme protein and I want to do mutation for active site residues surrounding the substrate.. How can I decide which amino acid should substitute the active site residue?
for example .. if there a methionine residue which from my basic information is hydrophobic..what type of amino acid I can change to ... a smaller amino acid like alanine.. a more polar amino acid or another hydrophobic residue... how can I decide ?
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