In our study, different patients were recruited with different ages for both Alzheimer's patients and healthy controls, and they also vary in their APOE genotypes. How can I correct these variables to make the comparison for CSF and serum tau and amyloid beta levels.
Why don't you stratify into age ranges and then match with APOE genotypes? This, in my opinion will give rise to more accurate inferences than pooling data that emanates from a wide range of ages.
I could not agree more with Prof. Onaolapo, but again it all depends on your sample size. MANOVAs with age and APOE genotypes as covariates may be acceptable.
Grouping patients will need more participants, but of course, will yield more reliable results. Thank you professors, I will try it.
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