Or you may want to change it to binary, for that use

https://github.com/abhijeetsingh1704/DNA-to-BINARY

If you still want to change it to numerical, change the nucleotide code in script and the script will change DNA to numerical.

By simply using SED in Linux? For example:

sed -i 's/A/1/g' genome.fasta

sed -i 's/U/2/g' genome.fasta

and so on

Fabiano Sillo

How about changes in fasta header with your suggestion?

Abhijeet Singh

by excluding headers from replacement, of course

example for replace "A" with "1":

sed -i -e '/^[^>]/s/A/1/g' genome.fasta

and so on