How to computationally simulate the effect of OM, Blebbistatin or Aficamten on electromechanical models of cardiomyocytes?

Mohamadamin Forouzandehmehr @Mohamadamin-Forouzandehmehr

28 January 2022 0 8K Report

I'm most interested in mechanistic methods similar to modifying myofilament cross-bridge cycling (e.g. DRX:SRX ratios) as used for Mavacamten in Conference Paper Mavacamten Efficacy in Mutation-specific Hypertrophic Cardio...

Or modifications of the thermodynamics of cross-bridge cycling regarding MgADP, Pi, H+, and MgATP.

OM: Omecamtiv mecarbil.

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