How should I calculate the cut off for lymph node ratio in colon cancer, using a national data set?
Masoud,
Have large data sets of LNR using Kaplan Meier Survival curves from term long follow up. Identifying disharmonic changes from in between the LNRs over time may ease to identify cutoff values (and a statistician may give hints going through your results.
LNR, LN harvest and survival: There is a publication of Raoof in BJS 103(12): 1731-7 on lymph node harvest in rectal cancer which may be interesting to you as well (not on pubmed yet).
And the publication of Xu et al. Lymph node yield is an independent predictor of survival in rectal cancer regardless of receipt of neoadjuvant therapy. J Clin Pathol. 2016 Dec 8. pii: jclinpath-2016-203995. doi: 10.1136/jclinpath-2016-203995. [Epub ahead of print]; 27932667
Our article on a reduced lymph node number in rectal ca following neoadjuvant therapy is attached. Hope this points into the direction of your large task.
Kind regards,
Dietrich Doll
Dear Masoud,
I guess I would group the LNR values into 10 to 20 groups and perform an ROC-analysis with the endpoint you are interested in. I would perform this on test cohort and use than the calculted cut-off in validation cohort.
Best regards
Bruno Märkl
Dear Dietrich, Thanks for your reply and sharing your interesting paper.
Dear Bruno, Thank you too for your excellent answer.
I will back to you after applying your suggested methods in the analyses.
Best regards,
Masoud
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