How to calculate Decision limit and Detection capability

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Abdelhak Maghchiche

To calculate Decision Limit (CCα) and Detection Capability (CCβ), use the following formulas:

- CCα = LOD + 1.64 × σ

- CCβ = LOQ

These values indicate the limits of detection and quantitation, respectively.

Dr Balamurugan Krishnamoorthy

Free Software:

There are various statistical software tools that can assist with these calculations, often as part of method validation packages. Some free options include:

R: The free software environment R, along with packages like qcc or custom scripts, can be used to calculate CCα and CCβ.
Python: With libraries such as numpy and scipy, Python can be used to perform these calculations.
LibreOffice Calc or Excel: Spreadsheet software can be used with formulas to calculate the parameters manually.

Additionally, some specific analytical method validation tools and calculators might offer free versions or trials, though they may be more specialized.

Jorge Antonio Custodio-Mendoza

Hi there! I´ve used DETARCHI software which is indeed ver easy to use in the calculation of CCA and CCB.

Article DETARCHI: A program for detection limits with specified assu...

You may contact the department of Chemistry from the University of Burgos, Spain to get the software.

Naga Veera Yerra

Finally i used "analyze it" software to calculate lod and loq. Thanks!