Dear Prajakta Bhende, what are the solution concentration and flow rate ? My Regards

https://doi.org/10.1002/pen.23704

Dear Prajakta,

It depends on many factors why the solution cligging insidd the needle.

Depends on the concentration od the polymer into the solution, type of solution, speed of injection, size of the needle, and even the temrature of the laboratory.

In my experiece I used Clroform/DMF 7/3 and 6%w/v polymer and using needle 27 guage and it was successful.

Best wishes,

Dear Prajakta Bhende,

because of high concentration of polymeric solution and its also low volatile solvent type using as well as other spinning parameters also influence during electrospinning.

According to my experience I have used TFA/DCM co-solvent system and 7% (w/v) of chitosan and gelatin 20% (w/v) and it was successfully prepared.

Abdelkader BOUAZIZ Respected Sir,

Thank you for your response and the suggested paper. We used 9 - 12wt% solutions (for both chloroform and DCM) with the flow rate set to 0.3-0.5ml/hr and voltage ranging from 16-19 kV

Moien Zarei Respected Sir,

Thank you for your response. May I know what was the flow rate and voltage used?

Yogendra Pratap Singh Respected Sir,

Thank you for your response.

Regards

Dear Prajakta Bhende,

Here is my article about it:

Article Evaluation of the effects of multiwalled carbon nanotubes on...

But anyway as I mentioned it depends on many factors and even in different electrospinning device you cannot get the same results with same parameters.

Optimization should be done.

chloroform and dichloromethane both are more volatile at room temperature. try to add DMF or DMSO with the above solvents (90/10 or 80/20 v/v%).

Dear Prajakta

mixing solvents is a simple way to avid this clogging if you can accept the changes it causes in scaffold characteristics. Otherwise have a look at this older question for more ideas.

https://www.researchgate.net/post/How-to-prevent-spinneret-blockage-when-electrospinning-with-chloroform

Dear Prajakta Bhende

You should decrease the ratio of high volatile solvent.

Article Maneuvering surface structures of polyvinylidene fluoride na...

https://doi.org/10.1177/0040517518792748

Best Regards