Dear All,
I have a list of SNPs and I want to test their enrichment in a selected loci from human genome. I know it is usual to do fisher exact test (one-sided) or alternatively hyper geometric test to show enrichment, but I would like to use the simulation tests to do this. I suppose simulation tests have greater efficiency in this regards.
I know Monte Carlo test could be implemented for this job, but I dont know how to do this! Is there a tool or R-code for doing that?
Does anybody have experience on performing Monte Carlo on human genome data?
Any comments would be appreciated greatly.
Well all the tests have been designed with a specific purpose. If you have a defined purpose then you should decide which of these tests is suitable for your investigation. If you need to read more on these tests, you will find all the information on PubMed, just as I have found too.
Surely PubMed and Google are first choice before asking any question. But in my case,-Doing Monte Carlo simulation on genomic data- I had no success.
Please post at SEQ Answers and Biostars for better responses. Just a suggestions. thanks.
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