We are finding (in Australia) that almost 50% of young adults (18-29 years) have used more than one drug in the previous year (most typically more than one of the following: alcohol, tobacco, cannabis, ecstasy, etc). Very interested in recent research on multiple drug use at a population level, as well as for specific subpopulations.
I encourage you to evaluate the NESARC, ADHEALTH, and NCS-R national datasets to answer your questions for the US. These are readily available for your use and will permit you to examine population prevalence rates and population segment rates. However, not all datasets include the same information, so you will have to tease out the issues of interest to you from each.
I expect that you will find polysubstance use more common than single substance use, after all, supply does not always equal demand so people make do.
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