I am preparing nanoemulsion of a herbal drug and after optimizing my oil:surfactant ratios now I would like to incorporate drug. But I don't know how much of drug should I incorporate into my formulation.
Amount to be incorporated is the actual dose of the drug that you expect to provide in a defined volume of formulation, which further depends on solubility of drug in oil phase. Make sure that the dose of drug is completely soluble in the oil phase and increase in the amount of oil phase may again increase the smix and water, which ultimately increases the volume and may lead to inconvenience in administration
The amount of drug to be loaded depends on the solubility in oil phase you use. Infact, selection of oil phase in general is done based on the solubility of drug in different oils which is a preliminary step to be followed besides plotting ternary phase diagram. In simple words, you see the solubility of drug - select the oil - select the surfactants - plot ternary phase diagram - optimise formulation.
try to study the solubility of ur compound in the oil phase hence, u can know the saturation state in it.
Find solubility of drug in your prepare formulation by same method which are performed in solubility study of oil. This give the idea, what amount of drug can be Incorporated.
In bioavailability studies are started with 40 mg/Kg of drug concentration. So first you need to calculate the drug for incorporating into the emulsion. If you plan to go for animal studies, like rat, you can't give 5ml or 10 ml. Then, you have to optimize the emulsion preparation process for the drug concentration.
You have to consider whether surfactant and drug will interact or not. E.g. drug may strongly depress the cloud point of nonionic surfactants.
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