Our study involves conducting multiple WBC countings of venous blood from healthy participants using a control and test diluting fluid. We plan to compare and evaluate the results by checking how close/far the WBC count of a sample with the test is from the control. We want to know of studies or articles that state what is the minimum sample size that will still yield statistically significant results.
MARBIL
Folks may find it difficult to answer your query as are many possible differences possible between two assessment methods (of blood dilution methods in this case). And each requires a different statistical – power-analysis (SPA) to determine sample sizes — so, suggest you to be more specific as to which is of interest ( or your purpose).
In this regard, two obvious basic concerns (IMO) —and arguably both — would be 1) respective reliabilities and their difference, and 2) respective means (and potential bias Of new dilution method vs. old- control).
“Sample-size“ also has several possible meanings depending on possibility of dividing a single persons sample into more than two subsamples , e.g. say 10 where alternating between dilution methods ( for relative independence) 5 are each would be ultimately produced. “Sample size’ also could mean the number of persons who provide a sample ( which might be divided as we just described).
Nonetheless: Given how you posed the question (sans specifics): One might guess you are interested in a quick eval where real ifocus is in use of new — maybe much faster or cheaper dilution method -- where WBC variation is “real interest.” In such a case, one might suggest selecting (~15) stratified sampled individuals ( animal or human) with WBCs over range of interest and then dividing into multiple even numbered sub samples ( GE. 6 , but 10 better).
Justification for the above could be provided, if it is on target. Most likely it is off in some significant way(s) , and to better advise would require a better statement of your underlying interest.
ALVAH
Alvah C Bittner, PhD, CPE
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