How many human protein kinases? Where to get the complete list of human kinases? Thanks!
Protein Kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families. By adding phosphate groups to substrate proteins, they direct the activity, localization and overall function of many proteins, and serve to orchestrate the activity of almost all cellular processes. Kinases are particularly prominent in signal transduction and co-ordination of complex functions such as the cell cycle. The diversity of essential functions mediated by kinases is shown by the conservation of some 50 distinct kinase families between yeast, invertebrate and mammalian kinomes. Of the 518 human protein kinases, 478 belong to a single superfamily whose catalytic domains are related in sequence. These can be clustered into groups, families and sub-families, of increasing sequence similarity and biochemical function.
The kinase dendrograms show the sequence similarity between these catalytic domains: the distance along the branches between two kinases is proportional to the divergence between their sequences. Seven major groups are labelled and coloured distinctly. For instance, the tyrosine kinases form a distinct group, whose members phosphorylate proteins on tyrosine residues, whereas enzymes in all other groups phosphorylate primarily serine and threonine residues. The relationships shown on the tree can in some instances be used to predict protein substrates and biological function for many of the over 100 uncharacterized kinases presented here. A further 40 ‘atypical’ kinases have no sequence similarity to typical kinases, but are known or predicted to have enzymatic activity, and some are predicted to have a similar structural fold to typical
https://www.cellsignal.com/contents/science/protein-kinases-introduction/kinases
Thank you all for the useful answers.
In MSigDB, there's a gene set named as GO_PROTEIN_KINASE_ACTIVITY (associated with GO term GO:0004672, with link http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY ), which contains 640 gens. Are these 640 all protein kinases?
In addition, MSigDB also contains another gene set, named as GO_KINASE_ACTIVITY (associated with GO term GO:0016301, with link http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY ), which contains 842 genes. Are these 842 all kinases?
Thanks!
Indeed they are. But you must have noticed the difference among the kinase activity. Protein kinase phosphorylate a protein as its substrate molecule, while Kinase could use any molecular as a substrate molecule. Thus protein kinase should be a sub-category of kinase protein. According to the kinase.com, there are 620 protein kinases (year 2002), and the protein kinases you found on broadinstitute website was based on the AMIgo annotation from 2017 (updated 2017), thus it is quite possible there the number has been increased from 620 to 640. Therefore, I would recommend to go for 640 human protein kinases, since your question was related to protein_kinases particularly.
Xue Zhang Abhijeet Singh I also have a similar question to Xue. I am looking for a subset of human kinase (in tissues) which are widely known for any particular type of cancer. Is there any such list available?
Any suggestions will be highly appreciated.
Thanks.
Mukta Sharma why do you mention me if you have question to Xue.
anyway
Article Kinase-targeted cancer therapies: Progress, challenges and f...
Article The role of oncogenic kinases in human cancer (Review)
https://www.jci.org/articles/view/76094
Article AMP-activated protein kinase and human cancer: Cancer metabo...
Abhijeet Singh beacuse you had answered her question so thought of asking you as well.
Thanks for the links
you can look at human protein atlas
https://www.proteinatlas.org/search/kinase
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