How exactly the deprotection of O-aetyl group in a glucopyranoside happens with K2CO3/MeOH mixture?

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Rafik Karaman

Dear Sai,

This reaction is called a base-catalyzed solvolysis in which K2CO3 is the base that catalyzes the solvolysis and MeOH is a solvent that attacks the acyl group and forms methyl acetate (transesterification) and the deprotected glucopyranoside.

Summary:

Glucopyranoside-O-(C=O)CH3 + K2CO3/MeOH = Glucopyranoside-OH + K2CO3 + CH3-O(C=O)CH3.

Hoping this will be helpful,

Rafik

Sai Siva Kumar P.

Thanks a lot Rafik Karaman sir.

Jagadeesh Kumar Ega

Acid catalysed deprotection by solvolysis under optimum conditions.

https://books.google.co.in/books?isbn=0080545262

www.springer.com/cda/content/.../cda.../9780387262512-c2.pdf?...0

www.rsc.org/suppdata/cc/c0/c0cc05580h/c0cc05580h.pdf

www.rsc.org/suppdata/sc/c1/c1sc00120e/c1sc00120e.pdf

Thank You Prof. Jagadeesh Kumar.