There are incidences of Falciparum malaria cases in my working place who have been de-inducted recently from South Sudan. According to the patients they were using Mefloquine prophylaxis weekly , However discontinued after de-induction(ideally should be consumed for 4 weeks after de-induction). What is the effectiveness of chemoprophylaxis and its mechanism
What should be an ideal way ahead? , besides active fever surveillance and health education about continuing prophylaxis and other personal protective measures like barrier clothing , use of repellents and mosquito nets
Kindly see the following RG link for insights.
Article Malaria chemoprevention and drug resistance: a review of the...
Generally recommended, but not 100% effective. Chemoprophylaxis prevents most diseases and death, whereby the resistance problem has to be considered. I always take in malaria-endemic regions 100 mg Doxycyclin per day (previously mefloquine once weekly). Since 40 years in tropical and malaria-endemic regions, I never had malaria. Prophylaxis needs to be taken until 4 weeks after leaving a malaria region (exception: Atovaquone-Proguanil; 1 week). Don´t forget: Malaria may occur even 1 year after exposure with recommended prophylaxis taken.
Drug chemoprophylaxis has proved to be an effective preventive strategy in travelers to malaria- endemic areas, both for P. falciparum and non-falciparum malaria, although it does not usually prevent the later relapses that can occur with P. vivax and P. ovale.
https://www.dovepress.com/compliance-with-primary-malaria-chemoprophylaxis-is-weekly-prophylaxis-peer-reviewed-fulltext-article-PPA
- Badges
- Science topic
- Similar topics
- Biological Science
- Molecular Biology
- Biomolecules
- Nucleic Acids
- RNA