This inquiry is related to a 2019 journal article authored by Nick Neuwinger et al., which explores the effect of underfilling vacuum blood collection tubes on the elevation of lactate dehydrogenase activity in both serum and heparin plasma samples. The conclusion drawn is that underfilling tubes causes a larger portion of blood to be aspirated at high velocity, resulting in elevated lactate dehydrogenase levels.
Nick Neuwinger et al. (October 2019) Underfilling of vacuum blood collection tubes leads to increased lactate dehydrogenase activity in serum and heparin plasma samples Retrieved on February 06, 2024 from Article Underfilling of vacuum blood collection tubes leads to incre...
In underfilled blood samples, the activity of lactate dehydrogenase (LD) differs across various collection tubes, with higher LD values observed in heparin plasma (HP) tubes compared to serum (SE) tubes. Specifically, underfilling of blood collection tubes led to higher LD values in both SE (+21.6%) and HP (+28.3%) tubes. This difference in LD activity between SE and HP tubes is important to consider when using LD as a risk stratification parameter, as HP tubes produce higher LD values. Therefore, distinguishing between SE and HP collection tubes is crucial when interpreting LD test results obtained from underfilled blood tubes. Additionally, it is recommended that diagnostic laboratories communicate LD test results from underfilled tubes with an attached comment highlighting the possibility of falsely elevated results.
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