Assume that I have a set of dependent variables and at least two independent variables (categorical). Assume that I'm interested in running an ANOVA or MANOVA with a full factorial model but my dependent variables are completely missing data for some combinations of the independent variables. How should this situation be handled in general and how does SPSS handle this? For example, if a certain interaction effect with a lot of missing data for its different combinations was considered as insignificant, how should this be interpreted?

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