This year's Nobel prize has gone for discovery of membrane vesicle trafficking of cellular materials like hormones, neurotransmitters, secretory vesicles - pinched off from Golgi body in animal and other eukaryotic cells - as they have elaborate ER, Golgi membrane system. Is this possible to have a similar to membrane vesicle trafficking process in prokaryotes, lacking cytoplamic membrane system. However, the linked paper brought first evidence of outer membrane bound secretory vesicles containing periplasmic secretions from gram negative microbes involved in trafficking bacterial molecules to eukaryotic host cells facilitating invasion of host. https://www.researchgate.net/publication/230817087_Electron_microscope_studies_of_surface_pilli_and_vesicles_of_Salmonella_310r-_organisms?ev=prf_pub
Article Electron microscope studies of surface pilli and vesicles of...
hi,
gram negative vescicles has some proteins, as the invasine and the adhesine, wich permitts the interaction with the eukariotic cells, also in vesicles are presents others moleculs presented in the gram negative membrane surface (ex.LPS) thus .. for example..for bone infection the use of vescicles by the bacterium is a way to create a favorable environment before the infection..vescicles aheres on the eukariotc cells inducing a responce after this the bacterium proveds the infections....there are a lot of paper dedicate to this... :)
Eleonora
Hi! Good discussion. Can you please mention exact reference on bone infection facilitated by membrane vesicles of bacteria?
I know some papers that reported outer membrane vesicles formed by bacteria. The vesicles are used for comunications between intra- or inter-species bacteria or for attacking other microbes or host cells.
For examples, list of some of the papers is as below.
I hope it helps.
J Bacteriol. 177(14):3998-4008 (1995)
Virulence factors are released from Pseudomonas aeruginosa in association with membrane vesicles during normal growth and exposure to gentamicin: a novel mechanism of enzyme secretion.
Nature 437(7057):422-425 (2005)
Membrane vesicles traffic signals and facilitate group activities in a prokaryote.
J Bacteriol. 195(13): 2971-2981 (2013)
Stress-Induced Outer Membrane Vesicle Production by Pseudomonas aeruginosa.
Terri N. Ellis et al. Microbiology And Molecular Biology Reviews,(2010),74, 81–94
Meta J. Kuehn and Nicole C. Kesty. Genes & Development (2005), 19, 2645–2655
these are my favourite...
Eleonora, Thanks.
Kingo, Thanks
The paper linked in the question from our lab of the year 1993 is likely the earliest report depicting in vivo/in situ/in tissue presence of outer membrane vesicles of any gram negative bacteria - and thus linking them with microbial invasion of host cells.
- Badges
- Science topic
- Similar topics
- Biological Science
- Cell Biology