We come across a lot of work considering the effect of lipid properties on liposome fluidity and fusogenic capacity, but what about particle size? Especially if the liposomes are a composed of the exact lipid composition.
Dear Salma Tammam ,
This seemingly simple question is quite a difficult one. Indeed, there is a lot that can be found in the literature, did you come across this one?: Article Morphological and Physical Analysis of Natural Phospholipids...
The difficulty lies in the fact that multiple factors are involved when looking at the fluidity of membranes. Obviously, the fluidity dependents on for example the acyl chains (saturated, unsaturated etc.). Another important factor is the curvature of the vesicles. If you talk about liposomes keep in mind what kind of liposomes one talks about, there is quite some difference between SUVs, LUVs and GUVs. In relation to this the type of lipid (and I mean not just the charge) is an important determinant as well. Are you familiar with polymorphic phases and corresponding dynamic molecular shapes concept? See for example:
Cullis, P. T., & Kruijff, B. D. (1979). Lipid polymorphism and the functional roles of lipids in biological membranes. Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes, 559(4), 399-420. (Figure 7)
Israelachvili, J. N., Marčelja, S., & Horn, R. G. (1980). Physical principles of membrane organization. Quarterly reviews of biophysics, 13(2), 121-200. (Figure 4.2)
I think if you rephrase your question to how curvature influence fluidity and fusogenic capacity you will find more precise answers. See for example:
Article The Lipid Composition and Physical Properties of the Yeast V...
Which links fluidity and curvature. Hope this helps you somewhat further.
Best regards.
The particle size not only affects in vitro characteristics, such as drug loading, aggregation, and sedimentation. And the particle size and the pharmacokinetic behavior and biodistribution of liposomes are closely related.
Liposome size is a significant parameter affecting drug loading, which determines the pharmacokinetics and pharmacodynamics of the drugs in circulation. In addition to their behavior in vivo, particle size also determines the solution stability of liposomes.
https://www.creative-biostructure.com/Mempro%E2%84%A2-Liposome-Size-Analysis-511.htm
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