See my project update on 08-26-2018 (Project: Is cytoplasmic pH a robust driver both of metabolism and psyche?")
"Cytoplasmic alkalosis provokes anaerobic glycolysis and lactate/pyruvate production. My knowledge is incomplete in this field. What kind of tissues produce lactate? How big is their capability? How does penetrate lactate through membranes? Etc. I know that penetration of lactate is slower than carbon dioxide, there is a time-gap between them. According to a publication the steady state did not develop in an hour – at least in the brain." http://n.neurology.org/content/35/12/1681.short
Article Hypocapnia and mental stress can trigger vicious circles in ...
Virtually all cells can produce lactate. If a cell can utilize carbohydrate for energy, it can produce lactate. By far the body's largest producer of lactate is skeletal muscle, partly because of its large energy requirements during work and exercise and partly because it is the largest tissue in the body (i.e., accounts for ~40% of the body mass). Lactate production by muscle under physiological conditions is greatest during high-intensity exercise when the energy requirement exceeds the rate of aerobic energy production. In this case, the greater the exercise intensity, the greater the lactate production. For many cell types, lactate transport in and out of a cell is primarily through a proton-linked monocarboxylate transporter.
Dear Gordon,
Thank you for your accurate answer. I am interested in hypocapnia-induced lactate production. I think the data are less available in this round. Agree?
I ask the question differently: Do you know that H+ ion production because of lactate production - provoked by hypocapnia alone - could overshoot hypocapnia alkalosis (intracellularly) or not? (If there is no hypoxia, muscular work, etc.)
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