This inquiry pertains to the study of Neuwinger, Nick et al. entitled "Underfilling of vacuum blood collection tubes results in elevated lactate dehydrogenase activity in serum and heparin plasma samples." I would like to know the effects of volume variation in blood samples on the accuracy of total cholesterol measurements in serum and heparin plasma samples.
Variations in blood sample volume can significantly impact the accuracy of total cholesterol measurements in serum and heparin plasma samples. Insufficient sample volume may lead to dilutional effects, resulting in lower cholesterol concentrations and inaccurate measurements. Contrarily, excess sample volume can cause interference and affect the reliability of test results. To minimize preanalytical errors and maintain consistent lipid profile testing, laboratories can implement strategies such as standardized blood collection protocols, training for phlebotomists to ensure proper sample collection, and the use of automated systems with volume detection capabilities. Regular quality control measures and proficiency testing also play crucial roles in ensuring the accuracy and reliability of lipid profile measurements.
Reference: Yin, P., Lehmann, R., & Xu, G. (2015). Effects of pre-analytical processes on blood samples used in metabolomics studies. Analytical and bioanalytical chemistry, 407, 4879-4892.
A number of things, including thawed samples, cracked vials, improperly sealed vials, empty vials, and severe hemolysis, can lead to unsatisfactory specimens. Inadequate specimens are recorded on the transmittal using the sample condition codes when they happen infrequently.
Reference. Kwiterovich, Peter. Laboratory Procedure Manual of Total Choloesterol.
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