Since ayurveda explains the concept of "Aasthapak and Nishtapak" about oral transformation of drug, so the question arises for Ayurvedic views about pharmacokinetics for non oral routes.
Dear Kumar Sir,
Thanks for your reply....!!!!
I agree with u But the question is regarding the Pharmacokinetics and your description is seems to be Pharmacodynamic. Can you please elaborate your views about the ADME (with special focus on Metabolism) of drug and or ayurvedic formulation given by non oral route
5 mahabhoota, 5 gnyanendriya & 5 karmendriya. for example pruthwi mahabhoota dominant gnayendriya is nasa. so nasal route acts on pruthwi principle in human body.
We need to understand ayurvedic epistemology first.
As far as i have understood, i can say that ADME is a concept learn't to understand the drug and its metabolites movement through out the body compartments (blood, liver, kidney, protein-bound, etc) and this concept being a universal concept for all the categories of drugs let it be allopathy, ayurvedic or homeopathic remains same. This means, ADME can be determined for any category of drug similar to any allopathic drug provided the measurement tools say LC-MS, NMR-MS, LC-NMR-MS, etc are precisely accurate even in NM or sub-NM concentration to measure the least amount of drug or metabolite in any compartment. The ADME is so universal that not only drugs, even food material can be evaluated for their metabolites. Hope my answer satisfy your doubts.
Dear Ankur Sir,
Thanks for your valuable inputs. I'm agree with you. But to integrate further we need to take account of ayurvedic views too, as likely said Dr. Prasad Sir.
Once again thank you all.... for your efforts and kind discusssion.
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