A handful of mutations to SARS-CoV-2 can help it to escape the immune response mounted by a subset of infected people.
https://www.nature.com/articles/d41586-020-00502-w
Preprint Comprehensive mapping of mutations to the SARS-CoV-2 recepto...
"The team tested the antibodies’ response to samples of the virus’s spike protein. Each sample protein carried different versions of a region called the receptor binding domain (RBD), which recognizes host cells and is a major target for antibodies.
Of thousands of RBD mutations tested, only a few reduced the antibodies’ ability to bind tightly to the spike protein — a change that might also indicate a reduction in the antibodies’ ability to disable the virus.
But the effects varied substantially between people. The most consequential mutations, at a location called E484, caused a steep drop in the potency of some individuals’ antibodies. Coronavirus variants identified in South Africa and Brazil carry a mutation at the same spot."
Coronavirus Cases:
92.834 million
Deaths:
1.988 million
Recovered:
66.385 million
Mutation itself adaptation of microorganisms and variation mutants always dangerous.
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