Can someone explain in simple terms how a Matching algorithm (used in DOCK, FLOG, LibDock and SANDOCK) work.
Hello! I have conducted a series of experiments for drug binding of a certain compound to HSA (serum albumin) such as fluorescence, UV-Vis, etc. Is it alright to publish my results without an...
09 October 2017 258 6 View
I am trying to find fluorescence of dyes in physiological pH, but I am not certain about the exc and em wavelengths of phosphate buffer.
11 December 2016 4,210 0 View
As I can observe from various papers, what can be the possible reason why NONOates are synthesized with very low temperature conditions? Is it because the multi-nitrogen species can react violently?
02 March 2016 1,824 0 View
Hi there. What method can I employ if I want to deprotec a Boc-protected secondary amine without using acid? or simply put some mild conditions for Boc deprotection without acid reagents.
02 March 2016 3,307 6 View
I am currently interested in biophotonics and I want to apply it to biochemical samples though I do not know how to begin. Would you help me brainstorm with this one?
31 December 2015 338 1 View
What computational chemistry tool can be best for this time of system, especially that phosphatidylserine and phospatidylethanolamine have interactions in the lipid bilayer?
31 December 2015 3,608 4 View
How to calculate the RMSD values for a MD simulation using MOE?
07 August 2021 0 0 View
When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.
16 June 2021 0 0 View
Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...
03 March 2021 5,978 5 View
Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...
02 March 2021 4,569 4 View
I am going to have 3 different probes in my qPCR work that I am going to do. But I realized that the machine we have in the lab is a Rotor-Gene Q 2plex HRM Platform, saying it has green, yellow,...
01 March 2021 8,544 1 View
Hi In Molecular Dynamics Simulation, how do I make changes to the force field according to my protein? I got this error in the add-ion stage: Fatal error "./ amber99sb-ildn-HHH.ff / force...
01 March 2021 8,747 4 View