Heavy metals deposited/stored/bound in certain tissues are unlikely to leave that tissue. A well known example is lead in bone tissue.

We have made it plausible https://www.researchgate.net/publication/270216139_Carryover_of_cadmium_from_feed_in_growing_pigs

that cadmium stored in kidneys will also stay there.

The big problem of heavy metals comes from their oxidation to become more harmful to biological molecules. To get rid of trace metals is to supply the body with all products that help their sequestration, reduce absorption, boost excretion...

Each metal needs a different treatment. I talkt about i t in myh book "Oligoelmentos en Medicina" Editorial Dunken. Buenos Aires.

Thank You Sir C.A. (Kees) Kan for your valuable comment.

Thank You Sir Cherif ABDENNOUR for your valuable answer.

Thank You Sir Luis Bertello for your valuable answer.

Enhancing natural chelation detoxification pathways, as well as use of pharmaceutical chelators against heavy metals are recomended

I am totally agree with Amel Amrani. First of all being with a suitable chelate, the detoxification mechanism should be operated and then the intake to the body should be limited.

Thank You Sir Amel Amrani for your helpful answer.

Thank You Sir Önder Duysak for your valuable answer.

Changing a diet is possible to do, such as diet of herbs and supplements, which help to break down metals into smaller molecules so they can be removed from urine, feces, sweat and even the breath.

source : https://draxe.com/heavy-metal-detox/

Hoping aswer your question

Thank You Sir Irwan Ramadhan Ritonga for your valuable answer.

Yes, I agree with what has been said.

Since we are exposed to heavy metals continuously and generally with very low doses, we also need continuously to eat food containing all elements (Zn, Ca, Se, vitamins, fibers, polyphenols, food containing thiol ...), which help lowering heavy metals by reducing their absorption firstly, and then enhancing the detoxification pathways especially by the liver, and increasing the excretions.

The answer depends on what heavy metals are involved.

Often our kidneys will manage to ger rid of metals absorbed from contaminated food, water or air. Only when intake exceeds the renal elimination capacity and there are health effects, the most efficient method is chelation therapy with BAL, DMS, DMPS or other chelators.

The most important point is of course prevention of exposure to high amounts of heavy metals.

Thank You Sir Cherif ABDENNOUR for your helpful answer.

Thank You Sir Frederik A. de Wolff for your helpful answer.