How do you rent a slot online from a high speed PC for doing some simulations?

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Alex Liberzon

http://www.mathworks.com/discovery/matlab-ec2.html

but it's much more convenient to switch to Python and then the whole thing would be free (not the supercomputer time, though) and much easier.

Frederik Wendelboe Lund

You may want to try Amazon EC2, see link below.

http://www.mathworks.com/discovery/matlab-ec2.html?refresh=true

James J Coyle

How about

and ask about pricing on the Amazon Cloud.

In your title you have High end PC , but in the text you have supercomputer.

Which do you need?