Binding of cytokines and some growth factors to their receptors activates STAT3, which is a type of transcription factor. How to understand that at a certain time, is STAT3 activated in the cell?
STAT3 activation is induced by phosphorylation on a critical tyrosine residue (Tyr 705) .
You can know its activation levels by using phospho Tyr705 STAT3 antibody in western blot.
https://www.cellsignal.com/products/primary-antibodies/phospho-stat3-tyr705-antibody/9131?Ntk=Products&Ntt=9131
STAT3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Western blot is most commonly used to detect the activation of STAT3 by using an antibody that is specific for the phosphorylated tyrosine705.
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