As the attached document from the company says in water at 25 C, but it does not work. Any ideas?
As the solubility of Cisplatin is very low in water how do you make it soluble?
did you changed the pH
No i have not did anything with pH , As there is nothing mentioned about the pH
.
Try solvent mixture in water so the dielectric constant will change....
try to use solubilizers may be this will help
Co solvent may be used
Dr. Amani what kind of solubilizers should i use and if i use the solublizer it may affect the composition of drugs
Water is not a good solvent for cisplatin. 0.9% NaCl is well recommended.
Cisplatin is highly soluble in DMF, so prepare a stock solution in DMF and dilute it with 0.9% saline or PBS.
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