I simply tried a pubmed search "(vitamin D) AND immune changes", 289 hits.

https://www.ncbi.nlm.nih.gov/pubmed?term=(vitamin%20D)%20AND%20immune%20changes

Thanks Rudolf and grateful.

289 hits....Just being simple here....if you could attach something specific or your own experience.Would be like a short-cut.

Already working on a project on Vitamin D, so wanted to know more on this subject.

Any way still try go through your list and grateful for that

Regards

Dr Sikandar

Here is a good, but older summary, that is open access

doi:10.3390/nu5072502

Dear Dr. Sikandar Hayat Khan

Please have a look at these useful RG links.

Article VITAMIN D IMMUNOMODULATORY EFFECT

Article Vitamin D and immune function: An overview

Article Vitamin D and Immune Function

Article Vitamin D and the Immune System

Article Vitamin-D in the Immune System: Genomic and Non-Genomic Actions

Good luck!

vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells and antigen presenting cells) and these immunologic cells are all are capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis.

Please check this link

Article Vitamin D and the Immune System

Low immune system efficiency: Vitamin D deficiency is linked to increased infection in the body, especially infection and respiratory infections, and is associated with autoimmune diseases such as type 1 diabetes, scleroderma, inflammatory bowel disease, and autoimmune rheumatism.

Vitamin D has important functions beyond those of calcium and bone homeostasis which include modulation of the innate and adaptive immune responses. Vitamin D deficiency is prevalent in autoimmune disease. Cells of the immune system are capable of synthesizing and responding to vitamin D. Immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D suggesting that the beneficial effects of supplementing vitamin D deficient individuals with autoimmune disease may extend beyond effects on bone and calcium homeostasis.

The classical, hormonal actions of vitamin D are related to mineral metabolism and skeletal health. Vitamin D enhances intestinal calcium and phosphate absorption, stimulates osteoclast differentiation and calcium reabsorption from bone and promotes mineralization of the bone matrix

I agree with Suaad Ali Ahmed

I think it is associated with vitamin D deficiency not only with osteoporosis but also with various health events that have nothing to do with the muscular system

I think lead Low immune system efficiency: Vitamin D deficiency is linked to increased infection in the body, especially infection and respiratory infections, and is associated with autoimmune diseases such as type 1 diabetes, scleroderma, inflammatory bowel disease, and autoimmune rheumatism.

It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. ... Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. Vitamin C is one of the biggest immune system boosters of all. In fact, a lack of vitamin C can even make you more prone to getting sick. ... Vitamin E is a powerful antioxidant that helps the body fight off infection.

The onset of autoimmune disease can be triggered by gluten, dairy products, leaky gut syndrome, infections, chronic stress, and vitamin D deficiency. ... A deficiency of vitamin D—lower than 30ng/ml in the blood—is associated with increased susceptibility to infections and autoimmunity. Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate

Regards

Following

vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells and antigen presenting cells) and these immunologic cells are all are capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can m​o​d​u​l​

Vitamin D is very important for the human bones. Deficiency of Vitamin D causes problems for the bones.

The researchers found that getting vitamin D, through exposure to patients with tuberculosis to the sun, had a positive effect on the immune system, and contributed to the treatment and mitigation of symptoms. Vitamin D is of great importance to the body and its immunity. And contributes to the prevention of many diseases. The most important sources: get it by exposing the skin to the sun, and at appropriate times, eating foods supported, eating mushrooms, or eggs or fish oil such as salmon, and in cases of severe shortage advised to go to eat in the form of dietary supplements.

Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. ... The classical actions of vitamin D are to promote calcium homeostasis and to promote bone health.

Vitamin D has proved to have important role in suppression of autoimmune diseases.

Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate .

The vital role of vitamin D in the human body is initially indicated by the discovery of vitamin D receptors (VDR) in almost all types of cells of the immune system, including neutrophils, monocytes, macrophages, dendritic cells, and T lymphocytes (CD4 and CD8) and B lymphocytes, modulating the innate and acquired immune response.

1,25 (OH) 2 D3-immunomodulator, oriented to different cells of the immune system.

Vitamin D is crucial for the activation of the immune system. Th1 and Th2 cells are direct targets for 1,25 (OH) 2D3. Vitamin D makes adequate immune response, restoring the attitude

pro-and anti-inflammatory cytokines

Besides the positive action of vitamin D on bones and teeth (known for many decades) there are a vast number of positive effects and associations. Just check the following reviews for example

Article Non-musculoskeletal Benefits of Vitamin D

Article Vitamin D in childhood and adolescence: an expert position statement

At present the majority of scientists involved in vitamin D acknowledge a positive effect on muscle performance and on the immune system as well. For example claims regarding muscle performance and improving the immune system have been approved to be used in vit D fortified food recommendations by the EFSA (European Food Safety Authority), e.g. EFSA Journal 2010; 8(2):1468

Of course those effects are only clinically seen when vit D is rather low, e.g. less than 25 nmol/L or 10 ng/mL and especially when such low vit D status is supplied to a level of at least 75 nmol/L or 30 ng/mL

Regarding the effects on the immune system, both native and adaptive (as discussed very well by colleagues Kazim and Maltsev earlier), some fine reviews are

Article Modulation of the Immune Response to Respiratory Viruses by Vitamin D

Article Vitamin D signaling in immune-mediated disorders: Evolving i...

Article Modulation of the Immune Response to Respiratory Viruses by Vitamin D

Concerning the relationship of vitamin D and respiratory tract infections or flue I point at

Article Vitamin D and Influenza—Prevention or Therapy?

Vt D involves in T cell activation