This question was asked to inquire into how incorporating regional antibiograms, which document local microbial resistance patterns, into diagnostic microbiology practices can help combat antibiotic resistance by guiding the selection of appropriate antibiotic therapies tailored to the specific resistance profiles in a given region. In addition, how do the overuse, misuse, and abuse of antibiotics contribute to the ongoing challenge of antibiotic resistance, and what strategies can be implemented to promote prudent antibiotic use for public health?