I need to synthesize PGA, but most of the literature says to remove residual monomer via refluxing in ethyl acetate or by performing a Soxhlet extraction in ethyl acetate. We don't have a Soxhlet extractor, so I'm wondering how to reflux in ethyl acetate, and how that removes residual monomer? I'm also interested if there are other methods for purification of PGA (ie. precipitation).
Link to Nature protocol suggesting reflux in ethyl acetate
Dear Sir,
This information will help you,
A particularly preferred embodiment of the invention comprises dissolving about one part by weight of the glycolide to be purified in methylene chloride, for example about 5% w/v, adding to the resulting glycolide solution about 0.1 part by weight of granulated alumina and stirring the resultant slurry for about 30 minutes, filtering to remove the alumina, evaporating the methylene chloride and drying the wet, purified glycolide so obtained under vacuum at a temperature of 45° to 50° C.
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