How do I connect terminals of amino acids without breaking?

01 July 2015 1 7K Report

I want to connect amino acids in cyclic form .when i connect last and first terminals it is breaking during energy minimization .so anyone knows is there any tools or software or how to do it manually -connecting first and last temini's ?

Andrew Kirkham

It sounds like you may have a case of "ring strain", which is a series of steric factors that leave you with bond lengths/angles that result in too much stress. It might be the case that your peptide chain is to short to cyclize.

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