27 February 2014 3 7K Report

When I tried to analyse the structural diversity of a peptide and its mutants, I found it is difficult to connect the probability of hydrogen bond formation of a residue with its propensity to acquire one kind of secondary structure. For example, residue A(i) exhibited considerable propensity to obtain α-helix, but the probability of backbone hydrogen bond formation between residue i and i + 4 was low. How to explain this phenomenon? STRIDE algorithm was applied to assign secondary structure of protein.

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