We synthesized highly purified thalidomide by ourselves and we have treated many patients with malignancies using thalidomide and celecoxib with good efficacy. But in Shizuoka Prefecture, I was ordered to cooperate the recall of thalidomide by the President of Shizuoka Prefecture(=Shizuoka Ken) because thalidomide synthesis is against the Law.. Our works are cited on many famous medical journals and textbook overseas. Japanese Government ordered not to conduct clinical trials for advanced patients with solid tumors. Because thalidomide is the dangerous drug and difficult to keep the patient safety. Moreover, many advanced cancer patients are refused to treat more after standard chemotherapy at Shizuoka Cancer Center, even if they could be estimated to recover with thalidomide and celecoxib. Please cooperate to help Japanese advanced cancer patients save their lives from Shizuoka Concentration Cancer Center. Without your helps, they have to die with the cease of respiration after injections of overdose morphine hearing the stream sound of high volume oxygen.
The present President of Shizuoka Prefecture is Heita Kawakatsu and Shizuoka Cancer Center is Ken Yamaguchi.
Masato Hada
Dr. Hada, I strongly suggest that you seek external sources of cooperation to perform a colaborative multicentric Clinical Trial for a specific cancer type that could be treated with thalidomide and celecoxibe in order to obtain Japonese Approval to your claim. Thalidomide in may country , for instance , despite its general use prohibition, has been approved to treat certain cases of Hansen’s Disease. I my self had experimentaly used it in mice to deaccelerate the Haber-Weiss reaction in association with montelukaste and ASA to avoid lung fibrosis. ( Caldas et al., 2002)
Thank you for your splendid answer.
I currently plan clinical trials for colorectal cancer and pancreatic cancer in foreign countries, but there are many difficult problems. If you have good information, let me know it.
Asbestos fibers causes pulmonary fibrosis (asbestosis), pleural abnormalities (effusion and plaques), and malignancies (bronchogenic carcinoma and mesothelioma)
Oxidative stress induced by asbestos exposure activates transcriptional factors such as nuclear factor κB (NF-κB) and activator protein 1 that govern cell proliferation, apoptosis, and inflammatory signaling.
Please mail the content below to this address.
https://s-kantan.jp/pref-shizuoka-u/offer/userLoginDispNon.action?tempSeq=18&accessFrom=
To Mr. President of Shizuoka Prefecture Heita Kawakatsu and Shizuoka Cancer Center Ken Yamaguchi.
We have known that many advanced cancer patients are refused to treat more after standard chemotherapy at Shizuoka Cancer Center, even if they could be estimated to recover with other treatments including thalidomide and celecoxib. They are ordered to select palliative care even though they have a chance to be saved with other treatments.
Please help Japanese advanced cancer patients save their lives from Shizuoka Concentration Cancer Center (President Ken Yamaguchi). They have to die with the cease of respiration after injections of overdose morphine hearing the stream sound of high volume oxygen.
The officials of Shizuoka cancer center bureau (Ken Yamaguchi, Mitsuhisa Kozakura) have neglect Dr..Hada’s protests.
Please improve the current worst and tragic situation at Shizuoka Cancer Center. Best regards
To Dr. Luiz Querino Caldas
Thank you for your cooperation.
It’s hard work for me, but please try again.
From the home page
https://s-kantan.jp/pref-shizuoka-u/offer/userLoginDispNon.action?tempSeq=18&accessFrom=
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An email has been sent to both Presidents Heita and Ken with our ideas of mutual collaboration.
To Dr. Luiz Querino Caldas
Thank you for your cooperation.
I hope Japanese patients with malignancies are helped by your mails.
Please continue to help me in another proposals.
Best Regards.
Masato Hada
I sent them the email under the name of my wife Marcia. You can use either [email protected] or [email protected], as you like.
The reply from Shizuoka Cancer Center was irresponsible and they try to conceal their mistakes without writing even the name of the person in charge.
Feb 18, 2019
You reached the Shizuoka Cancer Center with your previous email to the attention of Dr. Hada.
However, we are afraid that there is no "Dr. Hada" here.
Apparently you sent us the email by mistake.
Would you please check your record again and forward it to the right email address?
Thank you.
Best regards,
Shizuoka Cancer Center
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