Sattler S, Rosenthal N.  The neonate versus adult mammalian immune system in cardiac repair and regeneration. Biochim Biophys Acta 2016;1863(7 Pt B):1813-1821

The above article is insightful and I believe a key cornerstone to the dream of reparative medicine.  They have outlined the direction we should travel.  The question is how can the adult immune system be manipulated to act like a prenatal system?  This manipulation increases vulnerability to infections, so a strategy is also needed to protect the host from invaders while the immune system is altered during repair.