How can synthesis N1-benzylhistamine from reaction histamine with benzyl bromide ( in presence NaH as base and DMF as solvent ) ?

17 April 2023 1 6K Report

I try to synthesize N1-benzylhistamine

by meaning i need reaction happen at N1 of histamine not at primary NH2 group

It should work. The problem may be that benzylbromide reacts also with the amine NH2. You may acetylate the amine , run your condensation and after isolation of the compound, hydrolyse back to the amine.

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