It has shown that about gene knock out in mice'brain, the amount of other protein can be affected (Maybe in mRNA level or protein stability). I want to know whether point mutation can lead to the tangible changes.
It is not hard to imagine such a thing occurring. As an obvious example, a point mutation in a transcription factor could affect the production of several proteins whose transcription is regulated by that factor.
Dear Adam,
Yes that is right. but I ma wondering this is true just in case of TF. Point mutation in one protein ( not TF) can change other protein stability through changes in interaction. I am searching article which shows this.
Yes point mutation actually happens
can follow this paper
A point mutation affecting an SP1 binding site in the promoter of the ferrochelatase gene impairs gene transcription and causes erythropoietic protoporphyria.
Unless I have completely misunderstood the question, there are many other mutations that one could consider that are causative of disease states - for instance, mutations in proteins that are components of the proteasome, mutations of kinases or phosphatases that regulate protein degradation, sub cellular localisation etc.
ie - https://www.ncbi.nlm.nih.gov/pubmed/28438176
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