In residue analysis sample preperation is time and solvent consuming. so its may be better to use preperative HPLC for sample preperation.
Preparative chromatography is a scaled up for separation, purification of solutes in quantitative terms from a given sample. Sample preparation has to be done beforehand. Sample preparation should not be confused with preparative chromatography.
Link to ISOs: https://www.iso.org/committee/50160/x/catalogue/
If your matrices is liquid solid phase extraction is a good way to go about concentrating and extracting your sample. If your matrices is a solid you will need to go to a solvent extraction.
Preparative HPLC systems are used for large scale separations, sample purification, or to collect fractions for further analysis, not sample preparation.
For pesticide residue analysis, please use proper sample preparation (try a simple web search for example methods and techniques), an appropriate method and an analytical scale HPLC or GC system, as appropriate to the intended application.
I would suggest to use solid phase extraction cartridge (SPE) as a form of prep LC for your sample preparation. It can be selective if your compound is unique e.g. acid, base, or both. If you are looking for many compounds with different functionality, it will be useless because you will get some and lose some. What is your target analyte and how many. One way that I was doing is to use LC-MS/MS where you inject the sample extract (minimum cleanup like QuEChERS method) and use the LC column to do separation of your analytes from sample matrix and use MS/MS for selective detection.
I suggest for you QuEChERS extraction and cleanup procedure. It is a fast, simple, and effective alternative to conventional sample prep for multiresidue pesticide analysis GC/MS or LC/MS.
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