Hi Arnaldo,

We can best test the impact of acupuncture treatments  by using the 'Four Clinical Evaluation Techniques' ('si ping') of observing (wang') , listening/ smelling ('wen') , inquiring ('wen') and palpating ('qie'). This clinical evaluation technique can be administered, during and after the administration of the treatment. Using this technique of evaluation,the extent of the balance or  out of balance relationship between the Yang Anti-Pathogenic 'Qi' and Yin pathogenic Qi can be assessed. And in 1988, Yang Yu Shan re-arranged the 64 hexagrams to express genetic information through the sequence of the nucleotide base Adenine (A), Thymine (T), Guanine (G) and Cytosine (C). He used the Yang Yao 阳爻to represent the 'stronger' nucleoside C  and G; while using the Yin Yao 阴爻to represent the 'weaker' nucleoside U and A. In this way, the relationship and connectivity between the 64 symbolic systems of the 'Book of Change'and the system of genetic codes of the DNA, were expressed in a more concentrated manner. (Please refer to the paper that I uploaded to Researchgate 'The Use of Chronoacupuncture and Chemotherapy in treatment Lung Cancer as 'Kesou' (Cough) in Melbourne Australia : A clinical Report." 

Thanks Rey Tiiquia. This is an interesting approach. However, I'm looking for a type of "marker" that is measurable in terms of identifying changes in the epigenetic mark.

What about using a NMR spectroscopy/Gas chromatography/ Liquid Chromatography /metabolomics/genomics approach before/after placement and stimulation of ST 36?  It's the approach I'm trying to work out now to explore a different health intervention.  As a practicing acupuncturist though, I've been thinking it would be interesting to trial with acupuncture.

Thanks for you answer Joy. Does any of you suggestions measure, for instance, s4363657 which is a SNP in the SLCO1B1 gene, a gene that encodes a protein involved in the liver's uptake of certain drugs?

I believe it can if you use a targeted approach with proteomics.  Check out some of the new "omics" approaches.  It might involve partnering with an analytical chemist or laboratory that can run the targeted tests for you.