If the signal affected by noise generated on the detector and thus affect the calibration curve in analytical chemistry method. How can I reduce them?
What kind of detector?
Possible general improvements - cooling the detector to reduce thermal noise, operating off a battery and by passing the power supply with a capacitor reduce ground noise. For photodetectors, adding a light tube to reduce stray light contamination can also be a huge help.
To help you answer the question, you must tell us: exactly what type of detector you are asking about. What technique are you using (please be specific and provide the actual method and sample type)? Also, why do you think the noise you are observing is due to the detector alone? Often, "noise" is sourced to other areas of the analysis.
If you are currently using API probe, better you can opt APCI probe to reduce noise, subsequently response also decreases.
I don't know witch detector you talk about, but I answer about FID detector used in gaz chromatography (CPG )
Clean or replace the FID jet
Clean or replace the FID collector and Teflon insulators.
Inspect the underside of the brass castle assembly for rust or corrosion—replace if dirty.
When reassembling the FID make sure that all mechanical assemblies are tight and that the interconnect spring does not get deformed—it should be oriented into the channel on the outer perimeter of the FID collector.
Plug the FID column fitting to continue with the troubleshooting procedure.
Re-light the flame and bakeout the detector at 350 C for an hour.
Reevaluate the FID noise and background at normal FID and GC oven operating temperature.
If the noise and or background is still too high, the Air, H2 and Makeup gas purity is suspected. The FID can be operated with just Air and H2. Turn off the makeup gas and reevaluate the FID noise/background. If there is a significant drop in noise or baseline (>5pa drop in background) then the makeup gas purity is suspect. It is recommended at this point to replace traps in the Makeup Gas supply line. If the problem persists replace the moisture traps in the H2 and Air supply lines.
If the problem persists after gas purity issues are addressed, there could be a possible problem with the electronics
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