Add number of equivalents (one equivalent of amine (RNH2) for each tosyl group) in your compound.
Stir in aqueous ethanol (at ambient temperature) and follow by TLC
mant tahnks for your answer. i want to grafting of POSS-NH2 with TsO-Cyclodextrin.
In addition to Abdels method you will need to add equimolar amounts of a suitable non-nucleophilic base to quench the build-up of p-toluenesulfonic acid, for example potassium carbonate, triethylamine or Hunigs base for example. Failure to do so will result in protonation of your starting amine and so you would struggle to drive the reaction to completion. Additionally elevated temperature would probably be needed but start at room temp, monitor and increase if necessary. Hope this helps!
Yes, thanks Shaun, I forget to write 1 eq. of triethyl amine or pyridine
Could you introduce me article or reference about this process? I want to surface treatment of PLLA/POSS with CD
Shaun, you told me that i use non-nucleophilic material such as triethylamine. But triethylamin is nucleophilic. Could you tell me about this? Also how nucleophilic material reacts with p-toluenesulfonic?
The nitrogen in Triethylamine is indeed nucleophilic however it is sterically hindered by the attached ethyl groups. The nitrogen can thus only react with small electrophiles such as protons and so will be unlikely to react with your tosylated material. For these reasons triethylamine is often referred to as a 'non-nucleophilic base'.
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