06 May 2015 2 814 Report

A well established protocol was followed for drug loading. Unfortunately, the method seems not working. Is it necessary to have drug soluble in DMSO for loading? I tried to load drug by dissolving in THF and chloroform as my drug is not DMSO soluble. The drug loaded with THF and chloroform did not show any UV absorption peak after centrifugation/purification. However, it showed peak before purification. Please suggest me some suitable method for loading.

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