We want to induce hypocholestrolemia in rats to compare hypercholestrolemic rat testis?
I do not know your complete plan/idea but would comparison to naive control animals (not hypercholesterolemic) not suffice? or maybe if the method of inducing hypercholesterolemia is dietary, you might consider comparing to a group fed with a high cholesterol diet along with a cholesterol lowering agent (maybe chitosan or something...)
It seems possible to bring down cholesterol levels in hypercholesterolaemic rats, using for example chitosan, but bringing down cholesterol in naive control animals seems rather tricky....
i don't know, i am just saying...
Hello
If you want to induce acute hyperlipidaemia, you can use intraperitoneal injection of Triton WR-1339 according to http://www.hindawi.com/journals/omcl/2014/154295/ or poloxamer 407 http://www.ncbi.nlm.nih.gov/pubmed/9372476. Or you can use 1% cholesterol, 10% lard, 10% yolk powder and 79% normal diet. I think rice bran oil may induce insulin resistance depending on the period you will use it.
Hello
The best way I use in my research (Rat chow supplemented with 4% cholesterol and 1% cholic acid--CC diet)
Best regard
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