How can I find drugs (mediciens) affecting on the functional groups binding?

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What are the most effective strategies for integrating sustainability in your expertise?

What challenges do you think businesses or entities face in implementing these strategies? Thanks

28 July 2024 2,125 14 View

Is there any Impact of Interest Rate, Corruption Perception Index, and Economic Growth on Foreign Direct Investment in Developing Countries?

Is there any impact of the interest rate, corruption perception index, and economic growth on foreign direct investment in developing countries?

07 July 2024 770 7 View

Do you have any idea why I am getting these kind of chromatograms for my analytes (LC-MS/MS, mycotoxin, grains)?

I injected 28 mycotoxins individually and for 8 of them I did not get ant peaks and for 6 of them the peak shape is not good enough!

29 April 2024 3,641 5 View

Ion ratio value in LC-MS/MS?

Hi everyone, I analyzed some samples by LC-MS/MS, and I got a pretty good peak for quantifier ion, but the peak intensity for qualifier ion is not good enough so I got "ion ratio" as outlier...

21 February 2024 4,249 12 View

Outliers continue to appear after removal. What should I do?

Hello, I am trying to remove outliers from a dataset. I removed a few, but they continuously appear. What should I do? Please do not post AI generated answers.

16 January 2024 9,442 4 View

Determining the dataset: Paneldata or pooled cross sectional?

Hi everyone, i have a question regarding my dataset and would be grateful for any help: I have a dataset i downloaded online that gives me information about variables like Pool size, Dealvolume...

07 November 2023 1,005 5 View

Is there any difference between the measured TOC of catalytic high-temperature combustion at 680 C and 950 C?

Is it possible that TOC analyzing at 680 C cannot measure some organic compounds (e.g. high molecular weight compounds) in oilfield wastewater treatment?

06 November 2023 2,985 0 View

What is a protocol for adenovector production,titration and concentration?

I have an adenovector but the titration is very low and I need more of it.

05 November 2023 3,602 0 View

Is it possible to have considerable higher TOC removal than COD removal in wastewater treatment?

In the treatment of high salinity oilfield wastewater, we have much higher TOC removal than COD removal.

31 October 2023 965 2 View

How can i design a oligonucleotid library for morphine aptamer?

I want to design an aptamer for morphine by in sillico method and i need some basic sequence but i can not find them. if you have a library or know some article that can help me , please introduce...

27 October 2023 1,336 1 View

Is changing the medium during the experiment overestimate the results?

I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...

07 August 2024 2,283 2 View

Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

Determining the worth of a point improvement in Hamilton Depression Scale?

Dear readers, Thanks for your attention. I am wondering about the health economic problem of quantifying the value of interventions which a) prevent, b) improve symptom profile and c) ultimately...

05 August 2024 3,246 1 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

Can i quantify a nanoparticle encapsulated in cell culture medium by hplc?

Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...

03 August 2024 2,730 1 View

Conjugation of PEG-Amine to an Amino Acid Using EDC?

I am attempting to conjugate PEG to an amino acid at the C-terminus, for the purposes of producing nanoparticles. I have been told that PEG modified with amine groups can be used for this purpose,...

31 July 2024 2,033 1 View

Is it possible to use a safer acid instead of monochloroacetic acid to convert bacterial cellulose to carboxymethyl cellulose?

Hi, researchers, Is it possible to use a safer acid instead of monochloroacetic acid to convert bacterial cellulose to carboxymethyl cellulose?

29 July 2024 4,570 0 View

My cfDNA extraction protocol using silica beads works with plasma collected in COD SAGM bags but not with plasma collected in K2 EDTA tubes. Why so?

I am currently performing cell-free DNA (cfDNA) extraction from plasma using an in-house developed kit that employs silica-coated magnetic beads. My protocol works effectively with plasma obtained...

28 July 2024 3,559 0 View

How to maintain the drug concentration in cell culture study for long term?

I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...

24 July 2024 8,696 0 View

What is the Principle of Cysteine-carbazole-sulfuric acid reaction with glucose?

I have been looking for the principle of Cysteine-carbazole-sulfuric acid reaction in research papers and books, but couldn't find it. This reaction is mainly used for the quantification of...

23 July 2024 3,891 0 View