I have some nanocarriers which have drug and superparamagnetic nanoparticles inside them. The nanocarrier is made up of a thermo responsive material.
After application of an AC magnetic field, the magnetic nanoparticles are supposed to give heat that will cause structural change in the nanocarrier's material, thus drug release.
How do I check it? Can I use a regular induction heater?
Hi,
to study the heating effects of magnetic nanoparticles really requires a device designed for the purpose rather than a generic induction heater.
Further details on the following link
http://www.azonano.com/article.aspx?ArticleID=3853
Hi Mohd Qasim,
In fact you need a proper device to measure the "heat response" of the MNPs under application of an AC Magnetic Field. The price will depend on the design you want and this is strongly related to the response of your system. This means that with a regular design you may not be able to observe the "response" of your system.
If you are interested I can send you the contact of a colleague that has such a device and perhaps can help you.
Good luck,
Filipa
To study thermally-assisted drug release using the heating of magnetic nanoparticles, you need to verify several points:
1- That your nanocarrier is able to selectively release the drug above a certain temperature. You can test this just by increasing the temperature of your nanocarrier suspension with, say, a hot plate and a thermometer (ensuring that the temperature of your suspension is more or less homogeneous among all the volume). Then you can collect the supernatant and run some chemical characterization, such as HPLC, to detect your drug. Moreover, it is important that you also measure the drug release at room temperature, to actively show that the drug is only released during the high-temperature period.
2- That your magnetic particles are able to produce enough temperature increase so the drug gets released. To do so, you will need a special-purpose instrument, such as the one suggested by Carl Jones, wich will allow you to measure the temperature increase of your nanocarriers under the presence of an alternating magnetic field. There are other means of quantifying the heat generated by magnetic nanoparticles, you can find a review here:
http://informahealthcare.com/doi/abs/10.3109/02656736.2013.826825
3- That your nanocarrier is actually releasing the drug during alternating magnetic field application. To do so, you will need both the magnetic field applicator and the drug quantification technique you selected. Even if you don't detect a macroscopic temperature increase in the suspension, the heat generated by the magnetic nanoparticles can produce localized heating in the nanocarrier, thus releasing the drug.
I hope you find this useful, I did some work in this field.
- Badges
- Science topic
- Similar topics
- Chemistry
- Nanotechnology
- Nanostructured Materials
- Nanoparticles